OSTHOLE SYNERGIZES WITH HER2 INHIBITOR, TRASTUZUMAB IN HER2-OVEREXPRESSED N87 GASTRIC CANCER BY INDUCING APOPTOSIS AND INHIBITION OF AKT-MAPK PATHWAY

Background and Purpose: Although trastuzumab has shown considerable activity in the treatment of HER2-positive breast and gastric cancers, a significant proportion of patients do not respond to trastuzumab.Recent studies revealed that osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson possesses potent anti-tumor activity.Here, w

As evidence mounted that existing prevention methods would be insufficient to end the COVID-19 pandemic, it became clear that vaccines would be critical to achieve and maintain reduced rates of infection.However, vaccine-hesitant sentiments have become widespread, particularly in populations with lower scientific literacy.The non-STEM major (called

The internet was once seen as a new and definitive window to freedom and a world without torture.There is however, another Keypad less obvious but perhaps more notorious side: torturous environments can also be created through the internet; a place where individu- als may be targeted for discrimination, coer- cion or control.There is Makeup a deart